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Physical dependence on a prescribed medication would not signify addiction. Bodily dependence entails the occurrence of the withdrawal syndrome when there is sudden reduction or cessation in drug use or if an opiate antagonist is administered. Physical dependence may be detected following a couple of days of opioid therapy. Even so, clinically majo

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Acetaminophen is metabolized in the liver by using cytochrome P450 microsomal enzyme. About 8085% on the acetaminophen in your body is conjugated principally with glucuronic acid also to a lesser extent with sulfuric acid and cysteine. Just after hepatic conjugation, ninety to one hundred% of your drug is recovered in the urine with in the very fir

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